Fatalists think that everything is predestined and under no circumstances can it be changed. Buddhists do not acknowledge this viewpoint. Buddhism holds that even immutable karma can be changed with the attainment of realization of emptiness or true repentance. It is also owing to the view that compounded phenomena are not predestined, but can be improved, transformed and controlled, that we need to learn the Twelve Nidanas. It can be said that not knowing the Twelve Nidanas is in fact not knowing ourselves. 

~Depicted from FROM BELIEVERS TO BODHISATTVAS